| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynureninase |
|---|
| Ligand | BDBM50061907 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_91724 (CHEMBL702022) |
|---|
| IC50 | 100000±n/a nM |
|---|
| Citation |  Pellicciari, R; Natalini, B; Costantino, G; Mahmoud, MR; Mattoli, L; Sadeghpour, BM; Moroni, F; Chiarugi, A; Carpenedo, R Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J Med Chem37:647-55 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kynureninase |
|---|
| Name: | Kynureninase |
|---|
| Synonyms: | KYNU_RAT | Kynu |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52470.50 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_91725 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLS
LVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLM
KDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHG
LDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAG
HAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKP
ALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRK
SILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEK
RGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN
|
|
|
|---|
| BDBM50061907 |
|---|
| n/a |
|---|
| Name | BDBM50061907 |
|---|
| Synonyms: | (+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(+/-)-m-nicotinylbenzoylalanine] | 2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL23983 | meta-nitrobenzoyl)alanine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H10N2O5 |
|---|
| Mol. Mass. | 238.1968 |
|---|
| SMILES | NC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
