Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGastrin/cholecystokinin type B receptor
LigandBDBM82514
Substrate/Competitorn/a
Meas. Tech.ChEMBL_47969 (CHEMBL657472)
IC50 1.4±n/a nM
Citation Showell, GA; Bourrain, S; Neduvelil, JG; Fletcher, SR; Baker, R; Watt, AP; Fletcher, AE; Freedman, SB; Kemp, JA; Marshall, GR High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group. J Med Chem37:719-21 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gastrin/cholecystokinin type B receptor
Name:Gastrin/cholecystokinin type B receptor
Synonyms:CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48445.79
Organism:Homo sapiens (Human)
Description:Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM82514
n/a
NameBDBM82514
Synonyms:1-[[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-[(hexahydro-1H-azepin)-1-yl]-1H-1,4-benzodiazepin]-3-yl]-3-(3-methylphenyl)urea | CHEMBL543712 | L-737,415 | L-738416
TypeSmall organic molecule
Emp. Form.C24H29N5O2
Mol. Mass.419.5194
SMILESCN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)N1CCCCCC1 |c:9|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: