| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
|---|
| Ligand | BDBM50366618 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_33347 (CHEMBL646115) |
|---|
| Ki | 780±n/a nM |
|---|
| Citation |  Wetzel, JM; Miao, SW; Forray, C; Borden, LA; Branchek, TA; Gluchowski, C Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J Med Chem38:1579-81 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2B adrenergic receptor |
|---|
| Name: | Alpha-2B adrenergic receptor |
|---|
| Synonyms: | ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49964.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18089 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
|
|
|
|---|
| BDBM50366618 |
|---|
| n/a |
|---|
| Name | BDBM50366618 |
|---|
| Synonyms: | CHEMBL448620 | SNAP-5089 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H40N4O5 |
|---|
| Mol. Mass. | 608.7266 |
|---|
| SMILES | COC(=O)C1C(C(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)=C(C)N=C1C)c1ccc(cc1)[N+]([O-])=O |c:36,t:33| |
|---|
| Structure | 
|
|---|
Search and Browse
