Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50035350

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1468 (CHEMBL616591)

0.70±n/a nM

Citation

Ennis, MD; Stjernlöf, P; Hoffman, RL; Ghazal, NB; Smith, MW; Svensson, K; Wikström, H; Haadsma-Svensson, SR; Lin, CH Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. J Med Chem38:2217-30 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50035350

n/a

Name

BDBM50035350

Synonyms:

8-(Methyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde | CHEMBL71469

Type

Small organic molecule

Emp. Form.

C17H22N2O

Mol. Mass.

270.3694

SMILES

CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1

Structure