Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50033163 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138812 (CHEMBL747493) |
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IC50 | 4.7±n/a nM |
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Citation | Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Sawyer, BD; Mitch, CH; Deeter, JB; Peters, SC; Sheardown, MJ Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles. J Med Chem38:3469-81 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51390.46 |
Organism: | RAT |
Description: | P08482 |
Residue: | 460 |
Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50033163 |
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n/a |
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Name | BDBM50033163 |
Synonyms: | 3-(6-Chloro-pyrazin-2-yl)-1-aza-bicyclo[2.2.2]octane | CHEMBL102588 |
Type | Small organic molecule |
Emp. Form. | C11H14ClN3 |
Mol. Mass. | 223.702 |
SMILES | Clc1cncc(n1)C1CN2CCC1CC2 |(10.48,-2.69,;9.15,-1.91,;9.17,-.37,;7.82,.41,;6.49,-.36,;6.49,-1.9,;7.82,-2.67,;5.16,-2.67,;5.16,-4.21,;3.83,-4.97,;2.5,-4.21,;2.5,-2.67,;3.83,-1.89,;3.06,-3.22,;4.53,-3.62,)| |
Structure |
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