| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
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| Ligand | BDBM50030622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33355 (CHEMBL644759) |
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| Ki | 116±n/a nM |
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| Citation |  Ruffolo, RR; Bondinell, W; Hieble, JP Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem38:3681-716 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2B adrenergic receptor |
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| Name: | Alpha-2B adrenergic receptor |
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| Synonyms: | ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
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| Type: | Enzyme |
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| Mol. Mass.: | 49964.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18089 |
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| Residue: | 450 |
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| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
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| BDBM50030622 |
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| n/a |
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| Name | BDBM50030622 |
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| Synonyms: | (7aS,8S,11aS,12aR)-8-Methyl-5,6,7a,8,11a,12,12a,13-octahydro-7H-9-oxa-6a,13-diaza-indeno[2,1-a]anthracene-11-carboxylic acid methyl ester | AKUAMMIGINE | CHEMBL122404 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O3 |
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| Mol. Mass. | 352.4269 |
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| SMILES | COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12 |t:4| |
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| Structure | 
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