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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M4 | ||
| Ligand | BDBM50031098 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_139249 (CHEMBL746615) | ||
| Kd | 2.4±n/a nM | ||
| Citation |  McPherson, DW; Lambert, CR; Jahn, K; Sood, V; McRee, RC; Zeeberg, B; Reba, RC; Knapp, FF Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. J Med Chem38:3908-17 (1995) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M4 | |||
| Name: | Muscarinic acetylcholine receptor M4 | ||
| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 52841.70 | ||
| Organism: | RAT | ||
| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 | ||
| Residue: | 477 | ||
| Sequence: |
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| BDBM50031098 | |||
| n/a | |||
| Name | BDBM50031098 | ||
| Synonyms: | (E)-(R)-2-Hydroxy-5-iodo-2-phenyl-pent-4-enoic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester | CHEMBL127587 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22INO3 | ||
| Mol. Mass. | 427.2767 | ||
| SMILES | O[C@@](C\C=C\I)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |wU:9.8,1.18,wD:1.0,(7.75,-5.56,;6.42,-6.35,;6.42,-4.81,;7.75,-4.04,;7.75,-2.5,;9.1,-1.73,;5.07,-7.12,;5.07,-8.66,;3.74,-6.33,;2.41,-7.1,;2.41,-8.64,;1.08,-9.41,;.45,-8.43,;.45,-7.29,;1.08,-6.33,;-.25,-7.1,;-.25,-8.64,;7.75,-7.12,;7.73,-8.66,;9.06,-9.43,;10.41,-8.66,;10.41,-7.12,;9.08,-6.35,)| | ||
| Structure | 
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