| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50029912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28910 (CHEMBL638608) |
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| IC50 | 3300±n/a nM |
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| Citation |  Sugimoto, H; Iimura, Y; Yamanishi, Y; Yamatsu, K Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J Med Chem38:4821-9 (1996) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_MOUSE | Acetylcholinesterase (AChE) | Acetylcholinesterase (mouse AChE) | Acetylcholinesterase precursor | Ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 68165.65 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 614 |
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| Sequence: | MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
IACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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| BDBM50029912 |
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| n/a |
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| Name | BDBM50029912 |
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| Synonyms: | 2-(1-Benzyl-piperidin-4-yl)-5,6-dimethoxy-indan-1-one; hydrochloride | CHEMBL169648 | CHEMBL538296 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27NO3 |
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| Mol. Mass. | 365.4654 |
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| SMILES | COc1cc2CC(C3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC |
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| Structure | 
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