| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM50048324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144596 (CHEMBL747371) |
|---|
| IC50 | 9.2±n/a nM |
|---|
| Citation |  Fink, CA; Qiao, Y; Berry, CJ; Sakane, Y; Ghai, RD; Trapani, AJ New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11. J Med Chem38:5023-30 (1996) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85789.59 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07861 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
|
|
|
|---|
| BDBM50048324 |
|---|
| n/a |
|---|
| Name | BDBM50048324 |
|---|
| Synonyms: | (S)-3-(4-Hydroxy-phenyl)-2-[2-((S)-2-mercapto-3-methyl-butyrylamino)-2-methyl-propionylamino]-propionic acid | CHEMBL144543 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H26N2O5S |
|---|
| Mol. Mass. | 382.474 |
|---|
| SMILES | CC(C)[C@H](S)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
