| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM50036399 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_143915 (CHEMBL752718) |
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| IC50 | 0.140±n/a nM |
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| Citation |  Yokoyama, N; Walker, GN; Main, AJ; Stanton, JL; Morrissey, MM; Boehm, C; Engle, A; Neubert, AD; Wasvary, JM; Stephan, ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem38:695-707 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52661.52 |
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| Organism: | RAT |
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| Description: | thyroid beta 0 RAT::P18113 |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ
ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50036399 |
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| n/a |
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| Name | BDBM50036399 |
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| Synonyms: | Axitirome | CHEMBL159682 | N-(4-{3-[(4-Fluoro-phenyl)-hydroxy-methyl]-4-hydroxy-phenoxy}-3,5-dimethyl-phenyl)-oxalamic acid ethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24FNO6 |
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| Mol. Mass. | 453.4596 |
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| SMILES | CCOC(=O)C(=O)Nc1cc(C)c(Oc2ccc(O)c(c2)C(O)c2ccc(F)cc2)c(C)c1 |
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| Structure | 
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