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Targetthyroid beta
LigandBDBM18860
Substrate/Competitorn/a
Meas. Tech.ChEMBL_143914
IC50 1.8±n/a nM
Citation Yokoyama NWalker GNMain AJStanton JLMorrissey MMBoehm CEngle ANeubert ADWasvary JMStephan ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem 38:695-707 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
thyroid beta
Name:thyroid beta
Synonyms:Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1
Type:Enzyme Catalytic Domain
Mol. Mass.:52661.52
Organism:RAT
Description:thyroid beta 0 RAT::P18113
Residue:461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ
ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM18860
n/a
NameBDBM18860
Synonyms:(2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid | (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid | 3,5,3'-triiodo-L-thyronine (T3) | CHEMBL1544 | Triiodothyronine | Triiodothyronine (T3) | [125I]T3 | liothyronine | triothyrone
TypeHormone
Emp. Form.C15H12I3NO4
Mol. Mass.650.9735
SMILESN[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O |r|
Structure
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