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TargetThyroid hormone receptor beta
LigandBDBM50036416
Substrate/Competitorn/a
Meas. Tech.ChEMBL_143915 (CHEMBL752718)
IC50 400±n/a nM
Citation Yokoyama, NWalker, GNMain, AJStanton, JLMorrissey, MMBoehm, CEngle, ANeubert, ADWasvary, JMStephan, ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem38:695-707 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta
Type:Enzyme Catalytic Domain
Mol. Mass.:52661.52
Organism:RAT
Description:thyroid beta 0 RAT::P18113
Residue:461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ
ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50036416
n/a
NameBDBM50036416
Synonyms:2-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-phenylamino]-3-phenyl-propionic acid | CHEMBL350930
TypeSmall organic molecule
Emp. Form.C26H29NO4
Mol. Mass.419.5128
SMILESCC(C)c1cc(Oc2c(C)cc(NC(Cc3ccccc3)C(O)=O)cc2C)ccc1O
Structure
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