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Targetthyroid beta
LigandBDBM18862
Substrate/Competitorn/a
Meas. Tech.ChEMBL_143914
IC50 0.15±n/a nM
Citation Yokoyama NWalker GNMain AJStanton JLMorrissey MMBoehm CEngle ANeubert ADWasvary JMStephan ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem 38:695-707 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
thyroid beta
Name:thyroid beta
Synonyms:Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1
Type:Enzyme Catalytic Domain
Mol. Mass.:52661.52
Organism:RAT
Description:thyroid beta 0 RAT::P18113
Residue:461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ
ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM18862
n/a
NameBDBM18862
Synonyms:2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid | CHEMBL41632 | TRIAC | Tiratricol | Triiodothyroacetic acid, 3
TypeSmall organic molecule
Emp. Form.C14H9I3O4
Mol. Mass.621.9323
SMILESOC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
Structure
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