Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50036487 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54287 (CHEMBL666806) |
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Ki | 49±n/a nM |
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Citation | Rosowsky, A; Mota, CE; Queener, SF; Waltham, M; Ercikan-Abali, E; Bertino, JR 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem38:745-52 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50036487 |
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n/a |
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Name | BDBM50036487 |
Synonyms: | 5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-quinazoline-2,4-diamine | CHEMBL162270 |
Type | Small organic molecule |
Emp. Form. | C19H23N5O3 |
Mol. Mass. | 369.4176 |
SMILES | COc1cc(cc(OC)c1OC)N(C)Cc1cccc2nc(N)nc(N)c12 |
Structure |
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