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TargetDihydrofolate reductase
LigandBDBM50036486
Substrate/Competitorn/a
Meas. Tech.ChEMBL_216591 (CHEMBL874093)
Ki 72±n/a nM
Citation Rosowsky, AMota, CEQueener, SFWaltham, MErcikan-Abali, EBertino, JR 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem38:745-52 (1995) [PubMed]
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50036486
n/a
NameBDBM50036486
Synonyms:5-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-quinazoline-2,4-diamine | CHEMBL441298
TypeSmall organic molecule
Emp. Form.C19H22N4O3
Mol. Mass.354.403
SMILESCOc1cc(CCc2cccc3nc(N)nc(N)c23)cc(OC)c1OC
Structure
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