| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52979 (CHEMBL664187) |
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| IC50 | 3700±n/a nM |
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| Citation |  Rosowsky, A; Mota, CE; Queener, SF; Waltham, M; Ercikan-Abali, E; Bertino, JR 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem38:745-52 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23891.29 |
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| Organism: | Pneumocystis carinii |
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| Description: | n/a |
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| Residue: | 206 |
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| Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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| BDBM18512 |
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| n/a |
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| Name | BDBM18512 |
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| Synonyms: | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL36 | Pyrimethamine (Pyr) | US11530198, Example Pyrimethamine | cid_4993 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13ClN4 |
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| Mol. Mass. | 248.711 |
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| SMILES | CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 |
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| Structure | 
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