Reaction Details |
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Target | Dipeptidyl peptidase 2 |
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Ligand | BDBM50050517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53370 (CHEMBL884359) |
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IC50 | 21±n/a nM |
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Citation | Coutts, SJ; Kelly, TA; Snow, RJ; Kennedy, CA; Barton, RW; Adams, J; Krolikowski, DA; Freeman, DM; Campbell, SJ; Ksiazek, JF; Bachovchin, WW Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. J Med Chem39:2087-94 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dipeptidyl peptidase 2 |
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Name: | Dipeptidyl peptidase 2 |
Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
Type: | Protein |
Mol. Mass.: | 54339.29 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHL4 |
Residue: | 492 |
Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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BDBM50050517 |
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n/a |
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Name | BDBM50050517 |
Synonyms: | Boronic acid derivative | CHEMBL305170 | N-alkyl Gly-boro-Pro derivative |
Type | Small organic molecule |
Emp. Form. | C9H19BN2O3 |
Mol. Mass. | 214.07 |
SMILES | CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O |
Structure |
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