| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM50051804 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144459 (CHEMBL755106) |
|---|
| IC50 | 2.3±n/a nM |
|---|
| Citation |  Fournie-Zaluski, MC; Coric, P; Thery, V; Gonzalez, W; Meudal, H; Turcaud, S; Michel, JB; Roques, BP Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action. J Med Chem39:2594-608 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85570.75 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | NEP was purified to homogeneity from rabbit kidney. |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
|
|
|
|---|
| BDBM50051804 |
|---|
| n/a |
|---|
| Name | BDBM50051804 |
|---|
| Synonyms: | (2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylamino)-acetyl]-5-m-tolyl-pyrrolidine-2-carboxylic acid | CHEMBL427760 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N2O4S |
|---|
| Mol. Mass. | 426.529 |
|---|
| SMILES | Cc1cccc(c1)[C@H]1CC[C@H](N1C(=O)CNC(=O)[C@@H](S)Cc1ccccc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
