Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTranslocator protein
LigandBDBM50052741
Substrate/Competitorn/a
Meas. Tech.ChEMBL_37055 (CHEMBL652444)
Ki 1.8±n/a nM
Citation Campiani, GNacci, VFiorini, IDe Filippis, MPGarofalo, ACiani, SMGreco, GNovellino, EWilliams, DCZisterer, DMWoods, MJMihai, CManzoni, CMennini, T Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific"peripheral-type" benzodiazepine receptor ligands. J Med Chem39:3435-50 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50052741
n/a
NameBDBM50052741
Synonyms:CHEMBL325649 | Dimethyl-carbamic acid 5-naphthalen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
TypeSmall organic molecule
Emp. Form.C25H20N2O3
Mol. Mass.396.4379
SMILESCN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccc2ccccc2c1 |t:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: