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TargetPeripheral-Type Benzodiazepine Receptor
LigandBDBM50052754
Substrate/Competitorn/a
Meas. Tech.ChEMBL_37061
Ki 0.260000±n/a nM
Citation Campiani GNacci VFiorini IDe Filippis MPGarofalo ACiani SMGreco GNovellino EWilliams DCZisterer DMWoods MJMihai CManzoni CMennini T Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific"peripheral-type" benzodiazepine receptor ligands. J Med Chem 39:3435-50 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peripheral-Type Benzodiazepine Receptor
Name:Benzodiazepine receptors; peripheral & central
Synonyms:Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR)
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50052754
n/a
NameBDBM50052754
Synonyms:CHEMBL115740 | Diethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
TypeSmall organic molecule
Emp. Form.C23H22N2O3
Mol. Mass.374.4324
SMILESCCN(CC)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccccc1 |t:8|
Structure
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