Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50052747 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_37038 (CHEMBL650834) |
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IC50 | 1.3±n/a nM |
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Citation | Campiani, G; Nacci, V; Fiorini, I; De Filippis, MP; Garofalo, A; Ciani, SM; Greco, G; Novellino, E; Williams, DC; Zisterer, DM; Woods, MJ; Mihai, C; Manzoni, C; Mennini, T Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific"peripheral-type" benzodiazepine receptor ligands. J Med Chem39:3435-50 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50052747 |
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n/a |
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Name | BDBM50052747 |
Synonyms: | CHEMBL117444 | Dimethyl-carbamic acid 5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester |
Type | Small organic molecule |
Emp. Form. | C22H20N2O3 |
Mol. Mass. | 360.4058 |
SMILES | CN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1ccc(C)cc1 |t:6| |
Structure |
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