| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein, transpeptidase domain protein |
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| Ligand | BDBM50076680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153668 (CHEMBL758012) |
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| IC50 | >340000±n/a nM |
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| Citation |  Richter, HG; Angehrn, P; Hubschwerlen, C; Kania, M; Page, MG; Specklin, JL; Winkler, FK Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases. J Med Chem39:3712-22 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein, transpeptidase domain protein |
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| Name: | Penicillin-binding protein, transpeptidase domain protein |
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| Synonyms: | Penicillin-binding protein | Penicillin-binding protein 2b |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77257.38 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_153668 |
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| Residue: | 691 |
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| Sequence: | MLKRLKEKSNDEIVQNTINKRINFIFGVIVFIFAVLVLRLGYLQIAQGSHYKQIIKNDEN
ITVNESVPRGRILDRNGKVLVDNASKMAITYTRGRKTTQSEMLDTAEKLSKLIKMDTKKI
TERDKKDFWIQLHPKKAKAMMTKEQAMLADGSIKQDQYDKQLLSKIGKSQLDELSSKDLQ
VLAIFREMNAGTVLDPQMIKNEDVSEKEYAAVSQQLSKLPGVNTSMDWDRKYPYGDTLRG
IFGDVSTPAEGIPKELTEHYLSKGYSRNDRVGKSYLEYQYEDVLRGKKKEMKYTTDKSGK
VTSSEVLNPGARGQDLKLTIDIDLQKEVEALLDKQIKKLRSQGAKDMDNAMMVVQNPKNG
DILALAGKQINKSGKMTDYDIGTFTSQFAVGSSVKGGTLLAGYQNKAIKVGETMVDEPLH
FQGGLTKRSYFNKNGHVTINDKQALMHSSNVYMFKTALKLAGDPYYSGMALPSDISSPAQ
KLRRGLNQVGLGVKTGIDLPNETRGQIEPLTNNPGNYLDLSIGQYDTYTPLQLSQYVSTI
ANDGYRIQPHIGLTIHESTNKDEVGPLKKKINGTVLNKVNNTEKEIKQIQEGFKMAFNDK
DGTGYVSFKDTVVPTAGKTGTAEVFQNGEPRVNSTYIGYAPIDDPKLAFSIVYTNQPVPP
PWLTGGDLGRDVINYYFKQLGKDDKNKDKDK
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| BDBM50076680 |
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| n/a |
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| Name | BDBM50076680 |
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| Synonyms: | CHEMBL6461 | Ro-48-1220 | Sodium; (2S,3R,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate | Sodium; (2S,3S,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9N2O5S |
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| Mol. Mass. | 269.254 |
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| SMILES | C[C@]1(\C=C\C#N)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C([O-])=O |
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| Structure | 
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