Reaction Details |
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Target | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Ligand | BDBM50369165 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195256 (CHEMBL872978) |
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IC50 | 20±n/a nM |
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Citation | Moss, N; Beaulieu, P; Duceppe, JS; Ferland, JM; Garneau, M; Gauthier, J; Ghiro, E; Goulet, S; Guse, I; Jaramillo, J; Llinas-Brunet, M; Malenfant, E; Plante, R; Poirier, M; Soucy, F; Wernic, D; Yoakim, C; Déziel, R Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem39:4173-80 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Name: | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
Synonyms: | RRM1/RRM2 holoenzyme | Ribonucleoside-diphosphate reductase M1/M2 chain |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Ribonucleoside-diphosphate reductase large subunit |
Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
Type: | PROTEIN |
Mol. Mass.: | 90074.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_90946 |
Residue: | 792 |
Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2 |
Name: | Ribonucleoside-diphosphate reductase subunit M2 |
Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
Type: | PROTEIN |
Mol. Mass.: | 44868.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_195255 |
Residue: | 389 |
Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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BDBM50369165 |
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n/a |
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Name | BDBM50369165 |
Synonyms: | CHEMBL1169532 |
Type | Small organic molecule |
Emp. Form. | C32H54N6O9 |
Mol. Mass. | 666.806 |
SMILES | CC(C)C[C@@H](NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CC(=O)N1CCCC1)NC(=O)[C@H](NC(=O)NC1[C@@H](C)CCC[C@@H]1C)C(C)C)C(O)=O |r| |
Structure |
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