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TargetRibonucleoside-diphosphate reductase large subunit/subunit M2
LigandBDBM50050829
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195256 (CHEMBL872978)
IC50 440±n/a nM
Citation Moss, NBeaulieu, PDuceppe, JSFerland, JMGarneau, MGauthier, JGhiro, EGoulet, SGuse, IJaramillo, JLlinas-Brunet, MMalenfant, EPlante, RPoirier, MSoucy, FWernic, DYoakim, CDéziel, R Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem39:4173-80 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribonucleoside-diphosphate reductase large subunit/subunit M2
Name:Ribonucleoside-diphosphate reductase large subunit/subunit M2
Synonyms:RRM1/RRM2 holoenzyme | Ribonucleoside-diphosphate reductase M1/M2 chain
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Ribonucleoside-diphosphate reductase large subunit
Synonyms:RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit
Type:PROTEIN
Mol. Mass.:90074.67
Organism:Homo sapiens (Human)
Description:ChEMBL_90946
Residue:792
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2
Name:Ribonucleoside-diphosphate reductase subunit M2
Synonyms:RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit
Type:PROTEIN
Mol. Mass.:44868.59
Organism:Homo sapiens (Human)
Description:ChEMBL_195255
Residue:389
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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BDBM50050829
n/a
NameBDBM50050829
Synonyms:(S)-2-((S)-3-Carboxy-2-{(S)-2-[(S)-2-(3-isopropyl-ureido)-3-methyl-butyrylamino]-4-oxo-4-pyrrolidin-1-yl-butyrylamino}-propionylamino)-4-methyl-pentanoic acid | CHEMBL71721
TypeSmall organic molecule
Emp. Form.C27H46N6O9
Mol. Mass.598.6889
SMILESCC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(=O)N1CCCC1)NC(=O)[C@@H](NC(=O)NC(C)C)C(C)C)C(O)=O
Structure
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