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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM50054553
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52873 (CHEMBL666232)
IC50 36±n/a nM
Citation Kuo, EAHambleton, PTKay, DPEvans, PLMatharu, SSLittle, EMcDowall, NJones, CBHedgecock, CJYea, CMChan, AWHairsine, PWAger, IRTully, WRWilliamson, RAWestwood, R Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds. J Med Chem39:4608-21 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE
Type:PROTEIN
Mol. Mass.:42711.08
Organism:Mus musculus
Description:ChEMBL_1366444
Residue:395
Sequence:
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
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  Blast E-value cutoff:
BDBM50054553
n/a
NameBDBM50054553
Synonyms:(Z)-2-Cyano-N-(4-cyano-3-methyl-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide | CHEMBL358411
TypeSmall organic molecule
Emp. Form.C15H13N3O2
Mol. Mass.267.2826
SMILESCc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C#N
Structure
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