| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50054600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52874 (CHEMBL666233) |
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| IC50 | 23±n/a nM |
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| Citation |  Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds. J Med Chem39:4608-21 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT |
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| Type: | Enzyme |
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| Mol. Mass.: | 42672.97 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag. |
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| Residue: | 395 |
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| Sequence: | MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVR
VTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGIN
LGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQER
DALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIF
LGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
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| BDBM50054600 |
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| n/a |
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| Name | BDBM50054600 |
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| Synonyms: | (Z)-2-Cyano-3-hydroxy-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide | CHEMBL141047 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9F3N2O2 |
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| Mol. Mass. | 282.218 |
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| SMILES | FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C=C)cc1 |
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| Structure | 
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