Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetKappa-type opioid receptor
LigandBDBM50058149
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145567
Ki>3000±n/a nM
Citation Ohkawa SDiGiacomo BLarson DLTakemori AEPortoghese PS 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. J Med Chem 40:1720-5 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:KOR-1 | MSL-1 | OPIATE Kappa | OPRK1
Type:Enzyme
Mol. Mass.:42656.78
Organism:Mus musculus (Mouse)
Description:P33534
Residue:380
Sequence:
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50058149
n/a
NameBDBM50058149
Synonyms:7-(4'-Methoxy-2'-spiroindanyl)oxymorphone | CHEMBL298314
TypeSmall organic molecule
Emp. Form.C26H27NO5
Mol. Mass.433.4963
SMILESCOc1cccc2CC3(Cc12)C[C@@]1(O)C2Cc4ccc(O)c5OC(C3=O)C1(CCN2C)c45 |TLB:21:31:12:29.27.28,13:12:31.16.15:29.27.28,30:29:12:31.16.15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: