| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50029778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90070 (CHEMBL701321) |
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| IC50 | 60±n/a nM |
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| Citation |  Stewart, AO; Bhatia, PA; Martin, JG; Summers, JB; Rodriques, KE; Martin, MB; Holms, JH; Moore, JL; Craig, RA; Kolasa, T; Ratajczyk, JD; Mazdiyasni, H; Kerdesky, FA; DeNinno, SL; Maki, RG; Bouska, JB; Young, PR; Lanni, C; Bell, RL; Carter, GW; Brooks, CD Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. J Med Chem40:1955-68 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 77972.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
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| Residue: | 674 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG
CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE
AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY
YYLSPDRIPNSVAI
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| BDBM50029778 |
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| n/a |
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| Name | BDBM50029778 |
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| Synonyms: | CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]prop-2-ynyl}-N-hydroxyurea | N-{3-[5-(4-fluorophenoxy)furan-2-yl]prop-2-ynyl}-N-hydroxyurea |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11FN2O4 |
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| Mol. Mass. | 290.2465 |
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| SMILES | NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1 |
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| Structure | 
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