Ki Summary

Reaction Details

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Target

Melanocortin receptor 3

Ligand

BDBM50454568

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_106014 (CHEMBL716370)

IC50

50±n/a nM

Citation

Haskell-Luevano, C; Hendrata, S; North, C; Sawyer, TK; Hadley, ME; Hruby, VJ; Dickinson, C; Gantz, I Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. J Med Chem40:2133-9 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 3

Name:

Melanocortin receptor 3

Synonyms:

MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)

Type:

Enzyme

Mol. Mass.:

36044.86

Organism:

Homo sapiens (Human)

Description:

P41968

Residue:

323

Sequence:

MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG

BDBM50454568

n/a

Name

BDBM50454568

Synonyms:

CHEMBL263948

Type

Small organic molecule

Emp. Form.

C77H109N21O19S

Mol. Mass.

1664.884

SMILES

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |wU:8.10,77.79,36.36,111.116,26.29,95.99,wD:107.113,14.23,45.45,55.56,4.4,66.68,(7.2,-9.08,;5.9,-8.23,;5.99,-6.69,;4.69,-5.85,;4.77,-4.32,;3.48,-3.48,;2.1,-4.19,;2.03,-5.73,;.8,-3.35,;.89,-1.82,;2.27,-1.1,;-.56,-4.06,;-1.86,-3.21,;-1.77,-1.68,;-3.23,-3.92,;-3.32,-5.46,;-2.02,-6.3,;-2.09,-7.83,;-.79,-8.66,;.58,-7.97,;1.87,-8.8,;.66,-6.43,;-.64,-5.6,;-4.52,-3.08,;-5.88,-3.78,;-5.95,-5.32,;-7.19,-2.94,;-7.1,-1.41,;-5.74,-.71,;-8.56,-3.64,;-8.66,-5.18,;-10.01,-5.88,;-7.35,-6.02,;6.13,-3.62,;6.22,-2.08,;7.44,-4.46,;8.81,-3.76,;8.88,-2.22,;10.26,-1.51,;10.33,.02,;9.04,.86,;11.7,.74,;10.09,-4.6,;10.02,-6.13,;11.47,-3.9,;12.76,-4.74,;12.69,-6.27,;13.98,-7.1,;14.05,-8.64,;15.54,-9.04,;16.38,-7.74,;15.42,-6.54,;14.14,-4.03,;14.22,-2.49,;15.43,-4.85,;16.8,-4.15,;16.87,-2.62,;18.24,-1.92,;19.55,-2.76,;20.92,-2.06,;20.99,-.51,;19.7,.32,;18.33,-.38,;18.1,-4.99,;18.03,-6.53,;19.47,-4.29,;20.76,-5.13,;20.68,-6.67,;21.97,-7.51,;21.9,-9.04,;23.2,-9.88,;23.11,-11.42,;24.41,-12.26,;21.74,-12.12,;22.13,-4.43,;22.22,-2.9,;23.41,-5.27,;24.79,-4.57,;24.87,-3.04,;24.09,-1.68,;22.58,-1.41,;22.37,.12,;23.76,.78,;24.21,2.26,;25.71,2.61,;26.77,1.49,;26.33,.02,;24.84,-.33,;26.09,-5.4,;26.02,-6.94,;27.47,-4.7,;28.76,-5.53,;30.12,-4.83,;30.21,-3.29,;31.43,-5.67,;32.8,-4.97,;32.87,-3.43,;34.25,-2.73,;34.31,-1.2,;35.69,-.49,;35.77,1.05,;34.08,-5.81,;34.01,-7.34,;35.59,-5.22,;35.76,-6.74,;37.27,-7.04,;38.02,-5.71,;36.99,-4.57,;37.27,-3.06,;36.12,-2.03,;38.74,-2.57,;39.04,-1.06,;37.88,-.03,;38.18,1.47,;36.41,-.54,;40.5,-.56,;40.79,.95,;41.65,-1.57,)|

Structure