| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50059749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_37036 (CHEMBL650832) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Cappelli, A; Anzini, M; Vomero, S; De Benedetti, PG; Menziani, MC; Giorgi, G; Manzoni, C Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK11195). J Med Chem40:2910-21 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50059749 |
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| n/a |
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| Name | BDBM50059749 |
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| Synonyms: | 3-Methyl-4-phenyl-quinoline-2-carboxylic acid benzyl-methyl-amide | CHEMBL15248 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O |
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| Mol. Mass. | 366.455 |
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| SMILES | CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1 |
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| Structure | 
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