Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDNA topoisomerase 1
LigandBDBM50055659
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208415 (CHEMBL821422)
IC50 2700±n/a nM
Citation Zhao, Ral-Said, NHSternbach, DLLown, JW Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro. J Med Chem40:216-25 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA topoisomerase 1
Name:DNA topoisomerase 1
Synonyms:DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN
Type:Enzyme
Mol. Mass.:90771.02
Organism:Homo sapiens (Human)
Description:P11387
Residue:765
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50055659
n/a
NameBDBM50055659
Synonyms:2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-1H-2-pyrrolylcarboxamido]-1-methyl-1H-2-pyrrolecarboxamide | 2N-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1H-3-pyrrolyl]-4-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-1H-2-pyrrolecarboxamide | 2N-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1H-3-pyrrolyl]-4-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-1H-2-pyrrolecarboxamide(Distamycin) | 2N-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1H-3-pyrrolyl]-4-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-1H-2-pyrrolecarboxamide(distamycin A) | 4N-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-1H-2-pyrrolyl]-2-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-1H-4-pyrrolecarboxamide | 5N-[5-(3-amino-3-iminopropylcarbamoyl)-1-methyl-2,3-dihydro-1H-3-pyrrolyl]-3-(4-formamido-1-methyl-1H-2-pyrrolylcarboxamido)-1-methyl-2,3-dihydro-1H-5-pyrrolecarboxamide | CHEMBL101290 | CHEMBL11252 | DISTAMYCIN | DISTAMYCIN HYDROCHLORIDE | cid_6602691
TypeSmall organic molecule
Emp. Form.C22H27N9O4
Mol. Mass.481.5077
SMILESCn1cc(NC=O)cc1C(=O)Nc1cc(C(=O)Nc2cc(C(=O)NCCC(N)=N)n(C)c2)n(C)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: