Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 3A/3B | ||
Ligand | BDBM50060250 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2997 (CHEMBL872925) | ||
Ki | 10±n/a nM | ||
Citation | Heidempergher, F; Pillan, A; Pinciroli, V; Vaghi, F; Arrigoni, C; Bolis, G; Caccia, C; Dho, L; McArthur, R; Varasi, M Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding. J Med Chem40:3369-80 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A/3B | |||
Name: | 5-hydroxytryptamine receptor 3A/3B | ||
Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of EBI is 2974 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | 5-hydroxytryptamine receptor 3B | ||
Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
Type: | PROTEIN | ||
Mol. Mass.: | 50328.78 | ||
Organism: | Rattus norvegicus | ||
Description: | EBI_11885 | ||
Residue: | 437 | ||
Sequence: |
| ||
Component 2 | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 55428.70 | ||
Organism: | RAT | ||
Description: | 5-HT3 HTR3A RAT::P35563 | ||
Residue: | 483 | ||
Sequence: |
| ||
BDBM50060250 | |||
n/a | |||
Name | BDBM50060250 | ||
Synonyms: | 1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3-(3-nitro-phenyl)-imidazolidin-2-one | CHEMBL111882 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H20N4O3 | ||
Mol. Mass. | 316.355 | ||
SMILES | [O-][N+](=O)c1cccc(c1)N1CCN(C2CN3CCC2CC3)C1=O |TLB:12:13:17.16:19.20,(.04,-13.55,;.04,-15.09,;-1.28,-15.87,;1.38,-15.86,;1.38,-17.41,;2.71,-18.18,;4.05,-17.41,;4.05,-15.86,;2.71,-15.09,;5.37,-15.07,;6.77,-15.7,;7.8,-14.55,;7.03,-13.21,;7.64,-11.79,;7.87,-10.38,;9.13,-9,;10.93,-9.22,;10.64,-10.59,;8.81,-10.35,;8.26,-9.1,;8.68,-8,;5.52,-13.55,;4.37,-12.52,)| | ||
Structure |