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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Plasma kallikrein | ||
| Ligand | BDBM50060705 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_92238 (CHEMBL703583) | ||
| Ki | >1000000±n/a nM | ||
| Citation |  Tucker, TJ; Lumma, WC; Lewis, SD; Gardell, SJ; Lucas, BJ; Sisko, JT; Lynch, JJ; Lyle, EA; Baskin, EP; Woltmann, RF; Appleby, SD; Chen, IW; Dancheck, KB; Naylor-Olsen, AM; Krueger, JA; Cooper, CM; Vacca, JP Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position. J Med Chem40:3687-93 (1997) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Plasma kallikrein | |||
| Name: | Plasma kallikrein | ||
| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein | ||
| Type: | Protein | ||
| Mol. Mass.: | 71391.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P03952 | ||
| Residue: | 638 | ||
| Sequence: |
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| BDBM50060705 | |||
| n/a | |||
| Name | BDBM50060705 | ||
| Synonyms: | (S)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA | CHEMBL122894 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N3O2 | ||
| Mol. Mass. | 433.5857 | ||
| SMILES | NC1CCC(CNC(=O)[C@@H]2CCCN2C(=O)CC(c2ccccc2)c2ccccc2)CC1 |wU:9.8,(18.93,-14,;17.97,-12.81,;16.65,-12.04,;17.27,-10.34,;16.88,-9.19,;15.48,-8.55,;15.31,-7.01,;13.92,-6.4,;12.67,-7.29,;13.76,-4.86,;14.9,-3.83,;14.28,-2.42,;12.75,-2.58,;12.43,-4.09,;11.02,-4.7,;10.86,-6.24,;9.79,-3.8,;9.76,-2.26,;8.44,-1.49,;7.09,-2.26,;5.78,-1.49,;5.78,.05,;7.09,.82,;8.44,.05,;11.1,-1.49,;12.43,-2.26,;13.76,-1.49,;13.76,.05,;12.42,.82,;11.08,.05,;18.2,-9.96,;17.56,-11.56,)| | ||
| Structure | 
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