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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50061671
Substrate/Competitorn/a
Meas. Tech.ChEMBL_62884
Ki 0.30±n/a nM
Citation Mewshaw REKavanagh JStack GMarquis KLShi XKagan MZWebb MBKatz AHPark AKang YHAbou-Gharbia MScerni RWasik TCortes-Burgos LSpangler TBrennan JAPiesla MMazandarani HCockett MIOchalski RCoupet JAndree TH New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. J Med Chem 40:4235-56 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50061671
n/a
NameBDBM50061671
Synonyms:3-{[3-(3-Amino-phenoxy)-propylamino]-methyl}-2,3-dihydro-benzo[1,4]dioxin-6-ol | CHEMBL136635
TypeSmall organic molecule
Emp. Form.C18H22N2O4
Mol. Mass.330.3783
SMILESNc1cccc(OCCCNC[C@H]2COc3ccc(O)cc3O2)c1
Structure
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