| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50004665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138556 (CHEMBL746423) |
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| EC50 | 270±n/a nM |
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| Citation |  Messer, WS; Abuh, YF; Liu, Y; Periyasamy, S; Ngur, DO; Edgar, MA; El-Assadi, AA; Sbeih, S; Dunbar, PG; Roknich, S; Rho, T; Fang, Z; Ojo, B; Zhang, H; Huzl, JJ; Nagy, PI Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists. J Med Chem40:1230-46 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_MOUSE | Cholinergic receptor, muscarinic 1, CNS | Cholinergic, muscarinic | Chrm-1 | Chrm1 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51400.50 |
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| Organism: | Mus musculus |
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| Description: | Cholinergic, muscarinic 0 0::Q52KQ0 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50004665 |
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| n/a |
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| Name | BDBM50004665 |
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| Synonyms: | (oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one | 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one | 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one (oxotremorphine) | 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one(Oxotremorine) | 1-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-pyrrolidinium | CHEMBL7634 | Oxotremorine | Oxotremorine1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one | cid_4630 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N2O |
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| Mol. Mass. | 206.2841 |
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| SMILES | O=C1CCCN1CC#CCN1CCCC1 |
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| Structure | 
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