Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50039843 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138670 (CHEMBL748967) |
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Ki | 42±n/a nM |
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Citation | Messer, WS; Abuh, YF; Liu, Y; Periyasamy, S; Ngur, DO; Edgar, MA; El-Assadi, AA; Sbeih, S; Dunbar, PG; Roknich, S; Rho, T; Fang, Z; Ojo, B; Zhang, H; Huzl, JJ; Nagy, PI Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists. J Med Chem40:1230-46 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_MOUSE | Cholinergic receptor, muscarinic 1, CNS | Cholinergic, muscarinic | Chrm-1 | Chrm1 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51400.50 |
Organism: | Mus musculus |
Description: | Cholinergic, muscarinic 0 0::Q52KQ0 |
Residue: | 460 |
Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50039843 |
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n/a |
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Name | BDBM50039843 |
Synonyms: | 1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid prop-2-ynyl ester; hydrochloride | CHEMBL542065 |
Type | Small organic molecule |
Emp. Form. | C8H10N2O2 |
Mol. Mass. | 166.1772 |
SMILES | O=C(OCC#C)C1CNC=NC1 |c:9| |
Structure |
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