| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
|---|
| Ligand | BDBM50064537 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1159 (CHEMBL616104) |
|---|
| Ki | 0.34±n/a nM |
|---|
| Citation |  Reitz, AB; Baxter, EW; Codd, EE; Davis, CB; Jordan, AD; Maryanoff, BE; Maryanoff, CA; McDonnell, ME; Powell, ET; Renzi, MJ; Schott, MR; Scott, MK; Shank, RP; Vaught, JL Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem41:1997-2009 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1A |
|---|
| Name: | 5-hydroxytryptamine receptor 1A |
|---|
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46445.29 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Binding assays were performed using rat hippocampal membranes. |
|---|
| Residue: | 422 |
|---|
| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
|
|
|
|---|
| BDBM50064537 |
|---|
| n/a |
|---|
| Name | BDBM50064537 |
|---|
| Synonyms: | CHEMBL293658 | {3-[4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-piperazin-1-ylmethyl]-phenyl}-piperidin-1-yl-methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H31N3O3 |
|---|
| Mol. Mass. | 421.5319 |
|---|
| SMILES | O=C(N1CCCCC1)c1cccc(CN2CCN(CC2)C2COc3ccccc3O2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
