| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
|---|
| Ligand | BDBM50065823 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_89333 (CHEMBL702708) |
|---|
| Ki | 21±n/a nM |
|---|
| Citation |  Collins, JL; Shearer, BG; Oplinger, JA; Lee, S; Garvey, EP; Salter, M; Duffy, C; Burnette, TC; Furfine, ES N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem41:2858-71 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, inducible |
|---|
| Name: | Nitric oxide synthase, inducible |
|---|
| Synonyms: | HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 131141.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35228 |
|---|
| Residue: | 1153 |
|---|
| Sequence: | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
|
|
|
|---|
| BDBM50065823 |
|---|
| n/a |
|---|
| Name | BDBM50065823 |
|---|
| Synonyms: | CHEMBL555794 | N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamidine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H15N3S |
|---|
| Mol. Mass. | 209.311 |
|---|
| SMILES | CSCC(N)=Nc1cccc(CN)c1 |w:5.5| |
|---|
| Structure | 
|
|---|
Search and Browse
