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TargetAdenosylhomocysteinase
LigandBDBM50369381
Substrate/Competitorn/a
Meas. Tech.ChEMBL_196552
Ki 3600±n/a nM
Citation Wnuk SFMao YYuan CSBorchardt RTAndrei GBalzarini JDe Clercq ERobins MJ Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its"hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine. J Med Chem 41:3078-83 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosylhomocysteinase
Name:Adenosylhomocysteinase
Synonyms:Adenosylhomocysteinase
Type:PROTEIN
Mol. Mass.:47714.06
Organism:Homo sapiens (Human)
Description:ChEMBL_1507791
Residue:432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY
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  Blast E-value cutoff:
BDBM50369381
n/a
NameBDBM50369381
Synonyms:CHEMBL612194
TypeSmall organic molecule
Emp. Form.C11H11Br2N5O3
Mol. Mass.421.045
SMILESNc1ncnc2n(cnc12)C1O[C@@H]([C@@H](O)[C@H]1O)C(\Br)=C/Br |r|
Structure
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