| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50066173 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_205415 (CHEMBL812238) |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Walpole, C; Ko, SY; Brown, M; Beattie, D; Campbell, E; Dickenson, F; Ewan, S; Hughes, GA; Lemaire, M; Lerpiniere, J; Patel, S; Urban, L 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J Med Chem41:3159-73 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46261.42 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
|
|
|
|---|
| BDBM50066173 |
|---|
| n/a |
|---|
| Name | BDBM50066173 |
|---|
| Synonyms: | (S)-Pyrrolidine-1,2-dicarboxylic acid 2-{[(S)-1-(benzyl-methyl-carbamoyl)-2-naphthalen-2-yl-ethyl]-amide} 1-[(4-fluoro-phenyl)-amide] | CHEMBL108040 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H33FN4O3 |
|---|
| Mol. Mass. | 552.6385 |
|---|
| SMILES | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
