| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50066532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_149015 (CHEMBL758579) |
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| Ki | 1.6±n/a nM |
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| Citation |  Husbands, SM; Sadd, J; Broadbear, JH; Woods, JH; Martin, J; Traynor, JR; Aceto, MD; Bowman, ER; Harris, LS; Lewis, JW 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. J Med Chem41:3493-8 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50066532 |
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| n/a |
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| Name | BDBM50066532 |
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| Synonyms: | 1N-[4-cyclopropylmethyl-14-oxo-10-(2-propynyloxy)-(17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-17-yl]-3-(4-chlorophenyl)-(E)-2-propenamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31ClN2O4 |
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| Mol. Mass. | 543.053 |
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| SMILES | Clc1ccc(\C=C\C(=O)N[C@]23CCC(=O)[C@@H]4Oc5c6c(CC2N(CC2CC2)CC[C@@]346)ccc5OCC#C)cc1 |THB:17:18:10:22.28.27,30:19:10:22.28.27| |
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| Structure | 
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