| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50066910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_62972 (CHEMBL677462) |
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| IC50 | 6500±n/a nM |
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| Citation |  Campiani, G; Nacci, V; Bechelli, S; Ciani, SM; Garofalo, A; Fiorini, I; Wikström, H; de Boer, P; Liao, Y; Tepper, PG; Cagnotto, A; Mennini, T New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure. J Med Chem41:3763-72 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68497.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01959 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50066910 |
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| n/a |
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| Name | BDBM50066910 |
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| Synonyms: | (+/-)7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | (R)-(-)7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | (S)-(+)-7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene(ST1460) | 7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | CHEMBL120512 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20ClN3S |
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| Mol. Mass. | 333.879 |
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| SMILES | CN1CCN(CC1)C1Cn2cccc2Sc2ccc(Cl)cc12 |
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| Structure | 
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