| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50067070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40259 (CHEMBL656489) |
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| IC50 | 20±n/a nM |
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| Citation |  Hubschwerlen, C; Angehrn, P; Gubernator, K; Page, MG; Specklin, JL Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins. J Med Chem41:3972-5 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ENTCL | ampC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41306.67 |
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| Organism: | Enterobacter cloacae |
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| Description: | ChEMBL_40258 |
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| Residue: | 381 |
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| Sequence: | MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHY
YTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQ
WQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGA
LAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQA
YGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA
NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NTSYPNPARVEAAYHILEALQ
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| BDBM50067070 |
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| n/a |
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| Name | BDBM50067070 |
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| Synonyms: | CHEMBL355579 | sodium salt -tert-butyl 7-oxo-6-(sulfooxy)-2,6-diazabicyclo[3.2.0]heptane-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N2O7S |
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| Mol. Mass. | 307.301 |
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| SMILES | CC(C)(C)OC(=O)N1CCC2C1C(=O)N2OS([O-])(=O)=O |
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| Structure | 
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