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TargetMethylated-DNA--protein-cysteine methyltransferase
LigandBDBM50068784
Substrate/Competitorn/a
Meas. Tech.ChEMBL_144711 (CHEMBL751006)
IC50 70±n/a nM
Citation McElhinney, RSDonnelly, DJMcCormick, JEKelly, JWatson, AJRafferty, JAElder, RHMiddleton, MRWillington, MAMcMurry, TBMargison, GP Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain. J Med Chem41:5265-71 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methylated-DNA--protein-cysteine methyltransferase
Name:Methylated-DNA--protein-cysteine methyltransferase
Synonyms:6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:PROTEIN
Mol. Mass.:21651.27
Organism:Homo sapiens (Human)
Description:ChEMBL_144711
Residue:207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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  Blast E-value cutoff:
BDBM50068784
n/a
NameBDBM50068784
Synonyms:6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamine | CHEMBL150324
TypeSmall organic molecule
Emp. Form.C9H10N6OS
Mol. Mass.250.28
SMILESNC1=Nc2nc[nH]c2C(N1)OCc1cnsc1 |t:1|
Structure
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