| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50068813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54279 (CHEMBL669872) |
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| Ki | 0.000±n/a nM |
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| Citation |  Rosowsky, A; Wright, JE; Vaidya, CM; Bader, H; Forsch, RA; Mota, CE; Pardo, J; Chen, CS; Chen, YN Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523). J Med Chem41:5310-9 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50068813 |
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| n/a |
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| Name | BDBM50068813 |
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| Synonyms: | CHEMBL149962 | N-(4-Carboxy-4-{4-[(2,4-diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-butyl)-phthalamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N8O6 |
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| Mol. Mass. | 572.5719 |
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| SMILES | Nc1nc(N)c2cc(CNc3ccc(cc3)C(=O)NC(CCCNC(=O)c3ccccc3C(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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