Reaction Details | |||
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Target | Progesterone receptor | ||
Ligand | BDBM50062429 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_159052 (CHEMBL760814) | ||
EC50 | 2.7±n/a nM | ||
Citation | Edwards, JP; West, SJ; Marschke, KB; Mais, DE; Gottardis, MM; Jones, TK 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents. J Med Chem41:303-10 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Progesterone receptor | |||
Name: | Progesterone receptor | ||
Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone | ||
Type: | Protein | ||
Mol. Mass.: | 98979.52 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P06401 | ||
Residue: | 933 | ||
Sequence: |
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BDBM50062429 | |||
n/a | |||
Name | BDBM50062429 | ||
Synonyms: | 5-(4-Chloro-3-methyl-phenyl)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | CHEMBL94749 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H23ClFNO | ||
Mol. Mass. | 419.918 | ||
SMILES | CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(c4ccc(Cl)c(C)c4)c3c12 |t:1,(9.99,-5.01,;11.32,-5.78,;12.66,-6.55,;12.66,-8.1,;12.66,-9.64,;13.99,-7.33,;11.32,-8.86,;9.99,-8.07,;8.64,-8.86,;7.3,-8.07,;7.33,-6.55,;5.97,-5.78,;4.64,-6.55,;3.3,-5.78,;1.97,-6.55,;3.3,-4.23,;4.64,-3.46,;5.99,-4.23,;7.33,-3.44,;8.66,-4.23,;9.99,-3.46,;9.99,-1.93,;11.32,-1.15,;12.68,-1.93,;14.01,-1.17,;12.66,-3.48,;14.01,-4.26,;11.32,-4.24,;8.66,-5.78,;9.99,-6.55,)| | ||
Structure |