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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50062446 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3162 (CHEMBL617807) | ||
| IC50 | 1.4±n/a nM | ||
| Citation |  Rival, Y; Hoffmann, R; Didier, B; Rybaltchenko, V; Bourguignon, JJ; Wermuth, CG 5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists. J Med Chem41:311-7 (1998) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50062446 | |||
| n/a | |||
| Name | BDBM50062446 | ||
| Synonyms: | 3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-yl]-1-aza-bicyclo[2.2.2]octane | CHEMBL291031 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H20N4O | ||
| Mol. Mass. | 308.3776 | ||
| SMILES | Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12 |TLB:7:9:13.12:15.16,(12.88,-12.88,;12.86,-11.36,;14.15,-10.61,;14.15,-9.1,;15.23,-8.03,;15.22,-6.52,;17.81,-6.52,;17.81,-8.01,;16.53,-8.78,;19.22,-8.8,;19.22,-10.41,;20.52,-11.16,;21.34,-9.77,;19.78,-9.35,;20.6,-7.97,;22.01,-8.78,;22.01,-10.39,;11.53,-9.11,;10.22,-8.34,;8.91,-9.11,;8.91,-10.63,;10.22,-11.4,;11.55,-10.63,)| | ||
| Structure | 
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