Citation | Brady, SF; Stauffer, KJ; Lumma, WC; Smith, GM; Ramjit, HG; Lewis, SD; Lucas, BJ; Gardell, SJ; Lyle, EA; Appleby, SD; Cook, JJ; Holahan, MA; Stranieri, MT; Lynch, JJ; Lin, JH; Chen, IW; Vastag, K; Naylor-Olsen, AM; Vacca, JP Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support. J Med Chem41:401-6 (1998) [PubMed] Article |
---|
SMILES | CCCCC(CC(=O)N1CCC[C@H]1C(=O)NCC1CCC(N)CC1)c1ccccc1 |wU:12.13,(-.6,-12.34,;.31,-11.1,;1.84,-11.24,;2.74,-10,;4.27,-10.15,;4.9,-11.56,;6.43,-11.72,;7.05,-13.13,;7.34,-10.47,;6.71,-8.91,;8.11,-8.11,;9.35,-9.01,;8.88,-10.47,;9.77,-11.72,;9.15,-13.13,;11.31,-11.56,;11.93,-10.16,;11.52,-8.67,;12.71,-7.34,;11.41,-5.69,;11.43,-4.24,;11.99,-2.8,;10.24,-5.57,;11.52,-7.13,;5.17,-8.91,;3.83,-8.16,;3.83,-6.6,;5.16,-5.84,;6.49,-6.6,;6.5,-8.13,)| |