Ki Summary

Reaction Details

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Target

Acetylcholine receptor subunit alpha

Ligand

BDBM50049750

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_216982 (CHEMBL822799)

314±n/a nM

Citation

Holladay, MW; Wasicak, JT; Lin, NH; He, Y; Ryther, KB; Bannon, AW; Buckley, MJ; Kim, DJ; Decker, MW; Anderson, DJ; Campbell, JE; Kuntzweiler, TA; Donnelly-Roberts, DL; Piattoni-Kaplan, M; Briggs, CA; Williams, M; Arneric, SP Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. J Med Chem41:407-12 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Acetylcholine receptor subunit alpha

Name:

Acetylcholine receptor subunit alpha

Synonyms:

ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1

Type:

PROTEIN

Mol. Mass.:

52735.09

Organism:

Torpedo californica

Description:

ChEMBL_216981

Residue:

461

Sequence:

MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG

BDBM50049750

n/a

Name

BDBM50049750

Synonyms:

(S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Azetidin-2-ylmethoxy)-pyridine | A-159470 | A-85380 | CHEMBL59986

Type

Small organic molecule

Emp. Form.

C9H12N2O

Mol. Mass.

164.2044

SMILES

C(Oc1cccnc1)[C@@H]1CCN1 |r|

Structure