| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM13016 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_152398 (CHEMBL764114) |
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| Ki | 9700±n/a nM |
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| Citation |  Grunewald, GL; Dahanukar, VH; Jalluri, RK; Criscione, KR Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor. J Med Chem42:118-34 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM13016 |
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| n/a |
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| Name | BDBM13016 |
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| Synonyms: | 1,2,3,4-tetrahydroisoquinoline | CHEMBL14346 | THIQ 6 | tetrahydroisoquinoline |
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| Type | Small organic molecule |
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| Emp. Form. | C9H11N |
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| Mol. Mass. | 133.1903 |
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| SMILES | C1Cc2ccccc2CN1 |
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| Structure | 
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